PUBLICATIONS

A. Refereed Papers

  1. Chen, C.-H. (1984). A correlation goodness-of-fit test for randomly censored data. Biometrika, 71, 315-322. DOI: 10.2307/2336248.
  2. Evans, W.E., Stewart, C.F., Chen, C.-H., Crom, W.R., Bowman, W.P., Abromowitch, M. and Simone, J.V. (1984). Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia. Lancet, 8373, 359-362.
  3. Chen, C.-H. and George, S.L. (1985). The bootstrap and identification of prognostic factors via Cox's proportional hazards regression model. Statistics in Medicine, 4, 39-46. DOI: 10.1002/sim.4780040107.
  4. Zee, P., DeLeon, M., Roberson, P. and Chen, C.-H. (1985). Nutritional improvement of poor urban preschool children: A 1983-1977 comparison. Journal of the American Medical Association, 253, 3269-3272.
  5. Zee, P. and Chen, C.-H. (1986). Prevalence of obesity in children after therapy for acute lymphoblastic leukemia. American Journal of Pediatric Hematology Oncology, 8, 294-299.
  6. Taiwan Children's Cancer Study Group. (1989). Treatment of childhood acute lymphoblastic leukemia with protocol TCL821: A report of Taiwan Children's Cancer Study Group. Journal of the Formosan Medical Association, 88, 48-56.
  7. Chen, H.-Y., Hsieh, F.-J., Tseng, L.-H., Lee, C.-N., Chang, F.-M., Chen, J.-S.(C.-H.), Cheng, S.-J. and Kao, M.-L. (1991). Doppler waveforms study in normal Chinese fetus. Journal of Ultrasound in Medicine of the R.O.C., 8, 122-137.
  8. Chen, C.-H. and Wang, P.C. (1991). Diagnostic plots in Cox's regression model. Biometrics, 47, 841-850. DOI: 10.2307/2532643.
  9. Kuk, A.Y.C. and Chen, C.-H. (1992). A mixture model combining logistic regression with proportional hazards regression. Biometrika, 79, 531-541. DOI: 10.2307/2336784.
  10. Lin, F.-S., Heish, T.-S., Chiu, T.Y., Chen, J., Tsai, T.-C., Hsu, T.-C., Chiang, W.-H., How, S.-W. and Chen, C.-H. (1992). Clinic pathological study of the bladder tumor: Prognostic factors of 188 cases. Journal of the Urological Association of R.O.C., 3, 921-926. (In Chinese, with English abstract.)
  11. Hu, H.-H., Chung, C., Liu, T.J., Chen, R.C., Chen, C.-H., Chou, P., Huang, W.-S., Lin, J.C.T. and Tsuei, J.J. (1993). A randomized controlled trial on the treatment for acute partial ischemic stroke with acupuncture. Neuroepidemiology, 12, 106-113.
  12. Chen, C.-H., Chou, P., Hu, H.-H. and Tsuei, J.J. (1994). Further analysis of a pilot study for planning an extensive clinical trial in traditional medicine - with an example of acupuncture treatment for stroke. American Journal of Chinese Medicine, XXII, 127-136.
  13. Chang, I.S., Chen, C.-H. and Hsiung, C.A. (1994). Estimation in change-point hazard rate models with random censorship. In: Change-point Problems (E. Carlstein, H. G. Muller and D. Siegmund, eds.), Lecture Notes - Monograph Series Volume 23, 78-92. Institute of Mathematical Statistics, Hayward, California.
  14. Chi, K.-H., Chen, C.-H., Chan, W.-K., Chow, K.-C., Chen, S.-Y., Yen, S.-H., Chao, J-Y., Chang, C.-Y. and Chen, K.-Y. (1995). Effect of granulocyte-macrophage colony- stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. Journal of Clinical Oncology, 13, 2620-2628.
  15. Hwu, H.-G., Chen, C.-H., Rin, H., Chen, C.-J., Chang, S.-H., Huang, M.-G. and Yeh, J. J. (1996). The distribution of psychiatric beds in Taiwan. Chinese Psychiatry, 10, 45-53. (In Chinese, with English abstract.)
  16. Hwu, H.-G., Chen, C.-H., Rin, H., Chen, C.-J., Chang, S.-H., Huang, M.-G. and Yeh, J. J. (1996). Hospital locality and domicile of psychiatric inpatients. Chinese Psychiatry, 10, 166-174. (In Chinese, with English abstract.)
  17. Chen, C.-H., Tsai, W.-Y. and Chao, W.-H. (1996). The product-moment correlation coefficient and linear regression for truncated data. Journal of the American Statistical Association, 91, 1181-1186. DOI: 10.2307/2291736.
  18. Wu, A. C.-C., Huang, M.-K., Hwu, H.-G. and Chen, C.-H. (1999). Change of expressed emotion in the family members of schizophrenic patients over a two-year period. Taiwanese Journal of Psychiatry, 13, 54-64. (In Chinese, with English abstract.)
  19. Hwu, H,-G., Wu, A.C.C., Cheng, J.J., Huang, M,-G., Hu, S.-P., Chen, C.-H., Yeh, L.-L. and Chang, H.-J. (2000). The burden on chief caregivers of patients with schizophrenia. Taiwanese Journal of Psychiatry, 14, 205-217.
  20. Lin, C.-Y., Sheng, C.-C., Chen, C.-H., Lin, C.-C. and Chou, P. (2000). The prevalence of heavy proteinuria and progression risk factors in children undergoing urinary screening. Pediatric Nephrology, 14, 953-959.
  21. Wu, H.-D. I., Hsieh, F. and Chen, C.-H. (2002). Validation of a heteroscedastic hazard regression model. Lifetime Data Analysis, 8, 21-34.
  22. Hwu, H. G., Chen, C. H., Hwang, T. J., Liu, C. M., Cheng, J. J., Lin, S. K., Liu, S. K., Chen, C. -H., Chi, Y. Y., OuYoung, C. W., Lin, H. N. and Chen, W. J. (2002). Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admission. Schizophrenia Research, 56, 105-119. DOI: 10.1016/S0920-9964(01)00251-1.
  23. Wu, J.-F., Chen, C.-H., Hsieh, R.-P., Shih, H.-H., Chen, Y.-H., Li, C.-R., Chiang, C.-Y., Shau, W.-Y., Ni, Y.-H., Chen, H.-L., Hsu, H.-Y. and Chang, M.-H. (2006). HLA typing associated with hepatitis B e-antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan. Journal of Pediatrics, 148, 647-651. DOI: 10.1016/j.jpeds.2005.12.025.
  24. Su, L-J., Chang, C.-W., Wu, Y.-C., Chen, K.-C., Lin, C.-J., Liang, S.-C., Lin, C.-H., Whang-Peng, J., Hsu, S.-L., Chen, C.-H.* and Huang, C.-Y. F.* (2007). Selection of DDX5 as a novel internal control for Q-RT-PCR from the microarray data via the block bootstrap re-sampling scheme. BMC Genomics, 8: 140. DOI: 10.1186/1471-2164-8-140. (* Correspondence authors)
  25. Yeh, L.-L., Hwu, H.-G., Chen, C.-H., Chen, C.-H. and Wu, A. C. C. (2008). Factors related to perceived needs of primary caregivers of patients with schizophrenia. Journal of Formosan Medical Association, 107, 644-652. DOI: 10.1016/S0929-6646(08)60182-5.
  26. Huang, G.-H., Hsieh, C.-C., Chen, C.-H. and Chen, W. J. (2009). Statistical validation of endophenotypes using a surrogate endpoint analytic analogue. Genetic Epidemiology, 33, 549-558. DOI: 10.1002/gepi.20407.
  27. Lue, H.-H., Chen, C.-H. and Chang, W.-H. (2011). Dimension reduction in survival regressions with censored data via an imputed spline approach. Biometrical Journal, 53, 426-433. DOI: 10.1002/bimj.201000168.
  28. Huang, G.-H., Tsai, H.-H., Hwu, H.-G.*, Chen, C.-H., Liu, C.-C. Hua, M.-S. and Chen, W. J. (2011). Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry, 52, 469-478. DOI:10.1016/j.comppsych. 2010.10.012.
  29. Wu, J.-F., Su, Y.-R., Chen, C.-H., Ni, Y.-H., Chen, H.-L., Hsu, H.-Y., Wang, J.-L.* and Chang, M.-H.* (2012). Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotypes B and C HBV infected children. Journal of Pediatric Gastroenterology and Nutrition, 54, 97-100. DOI: 10.1097/MPG.0b013e31822a033e.
  30. Chiang, J.-T., Lin, C.-Y., Fu, T.-T. and Chen, C.-H. (2012). Using stated-preference and prior purchase intention in the estimation of willingness to pay a premium for genetically modified foods. Agribusiness, 28, 103-117. DOI: 10.1002/agr.20291.
  31. Liu, C.-C., Chen, C.-H., Hwu, H.-G., Shiu, S.-Y., Hua, M.-S., Chen, C.-H., Hwang, T.-J., Liu, C.-M., Hsieh, M.-H., Liu, S.-K. and Chen, W. J. (2012) Medium-term course and outcome of schizophrenia depicted by the sixth-month subtype after an acute episode. Journal of Formosan Medical Association, 111, 265–274. DOI: 10.1016/j.jfma.2011.01.007.
  32. Pan, Y.-J., Chang, W-H., Lee, M.-B.*, Chen, C.-H., Liao, S.-C. and Caine, E. D. (2013). Effectiveness of a nationwide aftercare program for suicide attempters. Psychological Medicine, 43, 1447-1454. DOI: 10.1017/S0033291712002425.
  33. Chen, C.-H., Tsay, Y.-C., Wu, Y.-C. and Horng, C.-F. (2013). Logistic-AFT location-scale mixture regression models with nonsusceptibility for left-truncated and general interval-censored data. Statistics in Medicine, 32, 4285-4305. DOI: 10.1002/sim.5845.
  34. Chen, C.-M. and Chen, C.-H. (2016). Heteroscedastic transformation cure regression models. Statistics in Medicine, 35, 2359-2376. DOI: 10.1002/sim.6896.
  35. Tsay, Y.-C., Chen, C.-H.* and Pan, W.-H. (2016). Ages at onset of 5 cardiometabolic diseases adjusting for nonsusceptibility: Implications for the pathogenesis of metabolic syndrome. American Journal of Epidemiology, 184, 366-377. DOI: 10.1093/aje/kwv449.
  36. Yang, H.-C., Chen, I-C., Tsay, Y.-C., Li, Z.-R., Chen, C.-h., Hwu, H.-G. and Chen, C.-H.* (2017). Using an event-history with risk-free model to study genetics of alcoholism. Scientific Reports, 7: 1975. DOI:10.1038/s41598-017-01791-4.
  37. Hsu, C.-Y., Chen, C.-H.*, Hsu, K.-N. and Lu, Y.-H. (2018). A useful design utilizing the information fraction in a group sequential clinical trial with censored survival data. Biometrics, published in Early View. DOI: 10.1111/biom.12925.

B. Statistical Software

  1. Tsay, Y.-C., Chen, C.-H., Wu, Y.-C. and Horng, C.-F. (2017). MixtureRegLTIC: Mixture regression models for left-truncated and interval-censored data. R package, version 1.0.0, https://CRAN.R-project.org/package=MixtureRegLTIC, Comprehensive R Archive Network.
  2. Hsu, C.-Y. and Chen, C.-H. (2018). SurvGSD: Group sequential design for a clinical trial with censored survival data. R package, Version 1.0.0, https://CRAN.R-project.org/package=SurvGSD, Comprehensive R Archive Network.

C. Conference Papers

  1. Chen, C.-H. and Wang, C.C. (1985). A clinical trial of Hepatitis-B vaccination in Taiwan. 28th Annual Conference, South African Statistical Association, Kruger National Park, South Africa.
  2. Chen, C.-H. (1988). Resampling methods in Cox's regression estimation. Pacific Regional Meeting of the Institute of Mathematical Statistics, Honolulu, U.S.A.
  3. Chen, C.-H. and Tsai, W.-Y. (1990). Nonparametric estimation of age-at-onset distribution using probands and kindreds combined data. 150th Annual Meeting of the American Statistical Association, Anaheim, California, U.S.A.
  4. Chen, C.-H., Shen, C.-Y. and Wang, J.-D. (1991). Multifactorial analysis of bladder and kidney cancer mortality rates around blackfoot disease endemic areas in Taiwan. Annual Conference, Chinese Statistical Association, Taipei, Taiwan, R.O.C.
  5. Shyu, C.-E. and Chen, C.-H. (1993). Statistical analysis of medical diagnostic data in matched studies. 1993 International Statistical Symposium, Taipei, Taiwan.
  6. Chen, C.-H., Lau, S.-K., Hwu, H.-G., Rin, H., Yeh, L.-L. and Chung, W.-C. (1994). Statistical analysis of time to re-admission for schizophrenic patients. Relapse of Schizophrenia: An International Conference, Kaohsiung, Taiwan.
  7. Chen, C.-H., Huang, H.-Y., Yeh, E.-K. and Chou, P. (1995). Estimation of the preclinical duration for cervical cancer from a one-examination screening program. 1995 Joint Statistical Meetings, Orlando, Florida, U.S.A.
  8. Wang, M., Chen, C.-H. and Chen, H. (1998). Analysis of a multi-path multi-state progressive disease with the consideration of non-susceptibility and phase-type distributions. 1998 Taipei International Statistical Symposium, Taiwan.
  9. Chen, C.-H. (2000). Quality assurance for the Pap smear test and natural history study of cervical cancer from mass screening data in Taiwan. Year-2000 Applied Statistics Symposium, International Chinese Statistical Association, Piscataway, New Jersey, U.S.A.
  10. Chen, C.-H. (2001). Regression models beyond proportional hazards in event history analysis. Invited Lectures, International Conference and Workshop on Recent Developments in Statistics and Its Applications, University of Malaya, Kuala Lumpur, Malaysia.
  11. Chen, C.-H. (2001). Statistical analysis of the length and the cost of stay in health insurance. The Tenth Annual Symposium of the Chinese Association of Applied Statistics, Hefei, China.
  12. Chen, C.-H. (2003). Modeling a multi-state disease process with phase-type distributions. Joint Statistical Meetings, San Francisco, U.S.A.
  13. Chen, C.-H., Lu, H. H.-S., Liao, C.-T., Chen, C.-h., Yang, U.-C. and Lee, Y.-S. (2003). Gene Expression Analysis Refining System (GEARS) via statistical approach: A preliminary report. The 14th International Conference on Genome Informatics, Pacifico Yokohama, Japan. Genome Informatics 14:316-317.
  14. Chen, C.-M. and Chen, C.-H. (2004). Practical survival analysis useful for predicting the association with microarray gene-expression profiling clusters. 2004 Taipei Symposium on Statistical Genomics, Academia Sinica, Taiwan.
  15. Chen, C.-H., Lu, H. H.-S., Liao, C.-T., Chen, C.-h., Lee, Y.-S., Tsai, C.-A., Chen , W.-K., Cheng, C.-C., Huang, H.-C., Yu, T.-W., Ho, M.-R., Chen, T.-B., Huang. C.-H., Lin, C.-R., Wu, C.-C. and Chang, C.-W. (2006). GESDAS: Gene Expression Study Design and Analysis Suite. International Chinese Statistical Association 2006 Applied Statistics Symposium, University of Connecticut, U.S.A.
  16. Chang, C.-W. and Chen, C.-H. (2007). Statistical inference on the partial AUC of the ROC regression for assessing diagnostic test accuracy with application to microarray gene expression analysis. 56th Session of International Statistical Institute, Lisbon, Portugal.
  17. Chen, C.-H. (2007). A statistical platform for microarray gene expression experiments and some studies in genomic statistics. The First Joint Meeting between ISSAS and ISM, Institute of Statistical Mathematics, Tokyo, Japan.
  18. Chen, C.-H., Tsay, Y.-C. and Pan, W.-H. (2008). Estimation of gene-environment interactions using mixture regression models with non-susceptibility. XXIVth International Biometric Conference, Dublin, Ireland.
  19. Chen, C.-H., Chiang, J.-T. and Fu, T.-T. (2009). Mixture regression models in the analysis of double-bounded dichotomous choice contingent valuation surveys. The 6th Cross-Strait Conference in Statistics and Probability, Nanjing University, China.
  20. Chang, W.-H., Chen, Y.-H. and Chen, C.-H. (2009). Case-cohort studies with non-susceptibility subject to right censoring and adjustment of entry ages. The 18th South Statistical Conference, National Sun Yat-sen University, Kaohsiung, Taiwan.
  21. Chiang, J.-T., Wang, Y.-B. and Chen, C.-H. (2009). Analysis of contingent valuation survey data with “don’t know” responses. 2009 Applied Statistics Symposium, National Taipei University, Taiwan.
  22. Chiang, J.-T., Chen, C.-H. and Fei, S.-Y. (2010). Multiple imputation for missing covariates in contingency valuation survey. 2010 Annual Conference, Chinese Institute of Probability and Statistics, National Dong Hwa University, Hualien, Taiwan.
  23. Chen, M.-H. and Chen, C.-H. (2010). Semiparametric analysis of transformation cure model with interval censoring. First Joint Biostatistics Symposium, Renmin University of China, Beijing, China.
  24. Chang, W.-H., Chen, C.-H. and Chen, Y. Q. (2011). An accelerated-proportional- additive regression model of mean residual life with an event-free fraction for censored data. Invited Session of New Frontier in Survival Analysis: Residual Life Analysis, 2011 Joint Statistical Meetings, Miami Beach, Florida, U.S.A.
  25. Chang, W.-H., Chen, C.-H., Chang, C.-M. and Lee, M.-B. (2012). Analysis of aftercare and associated factors for repeated suicide attempt: An application of semiparametric transformation cure model. 2012 Joint Statistical Meetings, San Diego, California, U.S.A.
  26. Wu, W.-M., Tsai, Y.-S., Lu, Y.-H., Chen C.-H.* and Yang, U.-C.* (2013). Design and conduct randomized clinical trials with the Clinical Study Information System. Best Paper Award, Joint Conference on Medical Informatics in Taiwan 2013, Taiwan Association for Medical Informatics. (In Chinese, with English abstract.)
  27. Hsu, K.-N. and Chen, C.-H. (2013). Semiparametric extended hazard cure models. 2013 Joint Statistical Meetings, Montreal, Canada.
  28. Tsay, Y.-C., Chen, C.-H. and Liao, C.-T. (2014). Nonparametric maximum likelihood estimators of an event-free fraction and an event time distribution for left truncated and interval censored data. International Biometric Conference, International Biometric Society, Florence, Italy.
  29. Tsai, C.-M., Lai, C.-L., Chiu, C.-H., Hsia, T.-C., Chen, C.-H., Chang, G.-C., Shih, J.-Y., Ho, C.-L., Chen, Y.-M. and Yang, J. C.-H. (2015). Maintenance with gefitinib/pemetrexed or pemetrexed alone after induction pemetrexed/platinum for stage IV lung adenocarcinoma with no sensitizing EGFR mutation (GENIUS trial). 16th World Conference on Lung Cancer, Denver, Colorado, U.S.A.
  30. Chen, C.-H. (2016). Statistical modeling for progression to cancer, targeted therapy and cure. Invited International Session 1: Methods of Integrative Mathematical Oncology, the 75th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan.
  31. Lin, Y.-R., Chao, W.-H. and Chen, C.-H. (2016). A generalized mover-stayer model for disease progressions with death adjusting for age at the study entry. Lifetime Data Analysis (LIDA) Special Invited Session, the 10th ICSA International Conference 2016, International Chinese Statistical Association, Shanghai, China.
  32. Tsay, Y.-C., Chen, C.-H. and Lai, M.-S. (2016). Logistic-AFT location-scale cure models for the relative survival with an application to HCV mono-infected patients. The 10th ICSA International Conference, International Chinese Statistical Association, Shanghai, China.
  33. Chen, C.-H., Tsay, Y.-C., Ou-Young, C.-W. and Lai, M.-S. (2017). Evaluating treatment effectiveness from nationwide population-based clinical databases. 2017 Joint Statistical Meetings, Baltimore, U.S.A.
  34. Hsu, C.-Y. and Chen, C.-H. (2017). Transformation cure models for enrichment design in targeted clinical trials. Invited Session 6: Analysis of Clinical Trial Data, the 2nd Pacific Rim Cancer Biostatistics Workshop, Kanazawa, Japan.
  35. Chiang, K.-M., Tsay, Y.-C., Wu, D.-C., Biradar, M., Yang, H.-C., Huang, Y.-T., Chen, C.-H. and Pan, W.-H. (2018). Hyperuricemia is an early onset metabolic disorder causally associated with cardiovascular disease event in Han Chinese. The American Society of Human Genetics 2018 Annual Meeting, San Diego, USA.

D. Book Review

  1. Chen, C.-H. (2000). Book Review for Research Methods – Guidance for Postgraduates. Tony Greenfield (ed.). Statistics in Medicine, 19, 3020.

E. Others

  1. Halpern, E., Albert, A., Aiuppa, T. and Chen, C.-H. (1977). Screening for the early detection of cancer, IV: Optimal screening policies for individuals. Department of Mathematics, Boston University Research Report, U.S.A.
  2. Albert, A. and Chen, C.-H. (1978). An approximately optimal screening policy with a continuous screening intensity. Department of Mathematics, Boston University Research Report #1-78, U.S.A.
  3. Chen, C.-H. (1981). Correlation-type goodness-of-fit tests for randomly censored data. Ph.D. Dissertation, Department of Statistics; Technical Report, No.73, Division of Biostatistics, Stanford University, U.S.A.
  4. Chen, C.-H., Wang, C.C. and Tai, J.J. (1985). Lecture Notes on Biomedical Statistics - Clinical Trials. Institute of Statistics, Academia Sinica, Taipei, R.O.C.
  5. Shyu, C,-E., Huang, H.-Y. and Chen, C.-H. (1991). Chinese translation of “Statistical guidelines for contributors to medical journals” (Altman, D.G., Gore, S.M., Gardner, M.J. and Pocock, S.J., British Medical Journal, 1983). Journal of Formosan Medical Association, 90, 318-323.
  6. Wang, Z., Chen, C.-H.*, Chang, W.-H. and Yang, Y. (2018). A semiparametric mixture regression model for case-control current status data. Submitted.
  7. Chen, C.-H.*, Tsay, Y.-C., Yang, H.-I.*, Lu, Y.-H. and Chen, C.-J. (2018). Non-susceptibility and incidence of hepatocellular carcinoma associated with hepatitis B virus genotype and mutants: Consideration of patient entry age in a follow-up study of the REVEAL-HBV cohort. Revised.
  8. Chiang, J.-T., Chen, C.-H., Fu, T.-T. Lai, W.-R. and Lai, C.-H. (2018). Regression models for the willingness-to-pay of two nested scenarios in a contingent valuation survey. Revised.
  9. Kuo, H.-H., Chen, C.-H., Chiang, J.-T.*, Lee, M.-B.* and Liao, S.-C. (2018). Identification of suicide ideation and associated risk factors for the elderly receiving home visit services: A longitudinal study based on Five-Item Brief Symptom Rating Scale. Revised.
  10. Lai, M.-Y., Hsu, C.-Y. and Chen, C.-H. (2018). One- and two-stage designs for stratified non-inferiority or equivalence clinical trials with count data. Manuscript.