Shieh Lab


Welcome to Shieh Lab.


Congratulations to our team members whose paper: "Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma," accepted by Oncotarget (2016).

Congratulations to our team members whose paper: "The overexpression of FEN1 and RAD54B may act as independent prognostic factors of lung adenocarcinoma," accepted by PLOS ONE (2015).


Bioinformatics at Taiwan International Graduate Program

Bioinformatics course at NTU

Research Topics

  1. Analysis of next generation sequencing data (e.g. ChIP-seq) and genomics data

  2. Using genetic interactions to develop cancer therapeutics

  3. Constructing gene networks/predicting pathway components

Research Projects

  1. Analyzing NGS ChIP-seq data to interrogate the role of (a) a co-factor in cancer cells. (b) small RNAs in cancer. (collaborate with (a) Prof. Lee-Young Chau (IBMS, Academia Sinica) and (b) Prof. Jan-Gowth Chang (China Medical Univ.).)

  2. Using genetic interactions to develop novel cancer therapeutics in colorectal cancer and lung cancer. (collaborate with Prof. Jan-Gowth Chang (China Medical Univ.), Jeou-Yuan Chen (IBMS, Academia Sinica) and Pan-Chyr Yang (National Taiwan Univ.).)

  3. Analyzing gene expression data (microarray or RNA-seq) to infer partial pathways involved in breast cancer stem cell (BCSC). (collaborate with Prof. Alice Chen (GRC, Academia Sinica).)

  4. Analyzing (a) Epigenetics, methylation binding domain (MBD) capture sequencing, (b) Microarray gene expression data and (c) microRNAs to uncover genes and pathways involved in ovarian cancer/endometrial cancer. (collaborate with Prof. Hung-Cheng Lai (National Defense Medical Center).)

  5. Using several kinds of genomic data to infer genetic interactions/pathway components.

Institute of Statistical Science, Academia Sinica, 128, Academia Rd. Sec. 2, Taipei 115, Taiwan