Shieh Lab

    

Welcome to Shieh Lab.

News

Congratulations to our team members whose paper: "H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast," accepted by the BMC Genomics (2011).

Congratulations to our team members whose paper: "Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model," accepted by the Carcinogenesis (2011).

Dr. Shieh has been appointed as an associate editor of 'Frontiers in Statistical Genetics and Methodology' ! (The journal website)

Congratulations to our team members whose paper: "Modeling and Comparing the Organization of Circular Genomes," published by the Bioinformatics (2011).



Teaching

Bioinformatics at Taiwan International Graduate Program

Bioinformatics course at NTU


Research Topics

  1. Analysis of genomics data

  2. Constructing gene networks/predicting pathway components

  3. Gene network integration/comparison

Research Projects

  1. Using genetic interactions to develop novel cancer therapeutic agents. (collaborating with Prof. Jan-Gowth Chang(Kaoshung Medical Univ.), Dr. Konan Peck(IBMS, Academia Sinica), Jeou-Yuan Chen(IBMS, Academia Sinica).)

  2. Analyzing microarray gene expression data to infer partial pathways involved in (a) carcinogenesis of Hepatocellular carcinoma in mouse. (b) obesity in human.
    (a) collaborating with Dr. C. H. Cathy Yuh at NHRI
    (b) collaborating with Drs. J. D. Zucker and Karine Clement, IRD and INSERM, FRANCE.

  3. Analyzing genomic data, Epigenetic (ChIP-chip, ChIP-sequencing) and gene expression data, to find novel biological phenomenon, e.g. chromatin remodeling in S. cerevisiae. (collaborating with Dr. Chen-Fu Kao at IOCB, Academia Sinica)

  4. Using several kinds of genomic data to infer genetic interactions / pathway components.


Institute of Statistical Science, Academia Sinica, 128, Academia Rd. Sec. 2, Taipei 115, Taiwan