注意 : 授課時間:每星期四上午09:10 ~12:00
授課地課:台大資工系107教室
生物資訊 Bioinformatics Spring 2007
授課負責教師
謝叔蓉
中央研究院統計科學研究所副研究員 國立臺灣大學醫工所兼任副教授
Syllabus
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Office:
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Institute of Stat. Sci. 305,
Academia Sinica
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Lecture time and
place:
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9:10~12:00 AM Thur. , 台灣大學資訊工程系107教室.
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Office hour:
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to be announced
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Pre-requisite:
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C and one
Statistics course (eg. Statistics, Regression Analysis , Multivariate Stat., etc.) for science and engineerin
background students, Statistics and Molecular and Cell Biology for biology
background students, or consent of the organizer.
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Grading:
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Homework (30%),
Midterm (40%), Term Project (30%).
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參考書:
1.
DNA from the BEGINNING : chaps. 16~41
2.
A
Primer of Genome Science, Greg Gibson and Spencer V. Muse, Sinauer
Associates, 2002
3.
Molecular
Cell Biology, Lodish et al. 4th edition,
NY: Freeman, 2000.
4.
Biologist's
Guide to Analysis of DNA Microarray Data and Microarray Analysis Set, M. Schena,
Wiley, 2002
5.
The Analysis of Gene Expression
Data, G. Parmigiani and E. S. Garrett, Springer, 2006
授課時間:
Thursday, 9:10 - 12:
00 A.M.
授課地點:
台灣大學資訊工程系107教室
這個生物資訊課程為跨領域的課程。希望理工背景的學生能由此獲得分生與生化基礎。而生物背景的學生能學得如何應用統計方法、資訊軟體與網路上資源,以奠定將來
從事生物資訊這領域研究的基礎,及獲得服務於生物科技企業界的基本訓練。
這課程第一部份涵蓋細胞分子生物學、生化學、癌症基因學、基因網絡(networks)、Biochemical pathways。第二部分為微晶片數據之介紹與分析、相關的統計方法與計算軟體(叢聚、分類等)的應用及基因網路的建構。第三部分將由客座講員主講基因功能學及蛋白體學方面的專門研究課題。
- 主題 1: Organization of the
course ( 1hr );
Molecular Biology I ( 2hrs )
授課教師: 任志鴻 (Genome center, N. Yang-ming Univ.)
授課日: Thursday, March 1st,
2007 Lecture
1
- 主題 2: Molecular Biology II
授課教師: 任志鴻 (Genome center, N. Yang-ming Univ.)
授課日: Thursday, March 8th,
2007 Lecture
2
- 主題 3: Molecular Biology for
reconstructing genetic networks
授課教師: 任志鴻 (Genome center, N. Yang-ming Univ.)
授課日: Thursday, March 15th,
2007 Lecture
- 主題 4: Microarray
gene expression data
授課教師: 謝叔蓉
授課日: Thursday, March 22th,
2007 Lecture1 Lecture2 R introduction Exercise
- 主題 5: Data Preprocessing for Affymetrix GeneChip Data
授課教師: 吳漢銘
授課日: Thursday, March 29th,
2007 Preprocessing Oligo
Filtering and MissingValues
Exercise
- No class on April 5th, 2007
- 主題 6: Finding Differential
Expressed Genes (including Case study using LimmaGUI
and affylmGUI)
授課教師: 吳漢銘 (中研院統計所)
授課日: Thursday, April 12th,
2007
Finding DEGenes Exercise
- 主題 7: Analysis of cDNA microarray Data
授課教師: 謝叔蓉
授課日: Thursday, April 19th,
2007 Normalization and clustering Analysis of Multi-array data R for microarray
Exercise 7
- 主題 9: Classification
methods and their applications:
Classify functions of genes and predict functions of unannotated genes.
授課教師: 謝叔蓉
授課日: Thursday, May 3th,
2007 classification R_classification
- 主題 10: Mid-Term Exam, Thursday, May 10th,
2007(Mid-Term Exam will include "Clustering" course)
- 主題 11: Yeast genomics
授課教師: 高承福 (Institute of Cellular and Organismic Biology, Academia Sinica)
授課日: Thursday, May 17th,
2007 Yeast genomics
- 主題 12: Reconstructing gene
networks and pathways I GNW_LDE
GNW_TIGP
授課教師: 謝叔蓉
授課日: Thursday, May 24th,
2007
- 主題 13: Gene Networks:
past, present and future Gene Networks
授課教師: 喻秋華 (NHRI, 分子基因醫學組)
授課日: Thursday, May 31th,
2007
- 主題 14: Reconstructing gene networks and pathways II Fuzzy
授課教師: 謝叔蓉
授課日: Thursday, June 7th,
2007
- 主題 15: Systems biology
授課教師: 王學偉 (陽明大學微免所)
授課日: Thursday, June 14th,
2007
- 主題 16: Project presentation
II Project1-1 Project1-2
Project2
授課日: Thursday, June 21th,
2007
地點:中央研究院統計科學研究所308會議室
FINAL EXAM : Term project.
Data sets:
GOOD LUCK AND HAVE A GREAT SEMESTER!
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