Artificial Intelligence (or Deep learning) and big data have attracted great attention in recent years. The availability of big data and advance in computation methods and capability further accelerate the development in machine learning. There is no doubt that AI will affect every aspect of our life in the future. In this talk, we discuss the following issues: (a) What is AI? (b) What is machine learning? (c) The role data play in the development of AI, (d) What are the potential impact of AI? And (e) How to prepare for the AI challenges? The talk will emphasize on the value of data and the importance of statistical reasoning and methods in the development of smart AI.