Applications of Bioinformatics in Precision Medicine

Abstract

The aim of the precision medicine is to develop the patient-tailored treatment or management. Up to date, microarrays, next generation sequencers, and LC MS/MS can be used to measure changes of different molecular levels such as genome, transcriptome, and proteome. It enables researchers to set up patient-tailored treatment or management based on molecular background. However, how to analyze above big molecular data and link to clinical information raise challenges in the precision medicine. In addition, heterogeneity of genomic backgrounds of different races is also an important issue. Hence, developments of bioinformatics approaches can overcome above challenges. In this talk, in the post-diagnosis, integrations of biological pathways and prognosis will be introduced. In the disease screening, whole genome sequencing approach will be demonstrated to identify a germline risk allele of lung adenocarcinoma. In the druggable target identifications, a web-based tool for transcription factor analysis will also be introduced. Furthermore, analysis of genomic backgrounds of different races and diseases will be discussed. Finally, pharmacoecnomics issue of targeting therapies will be also mentioned.