Pathway Enrichment Analysis: Current Approaches and Outstanding Challenges

Abstract

Pathway Enrichment Analysis: Current Approaches and Outstanding Challenges George Michailidis Department of Electrical Engineering and Computer Science, University of Michigan, USA ? Pathway enrichment analysis has become an important tool for biomedical researchers for gaining insight into the underlying biology of differentially expressed genes/proteins/metabolites, as it reduces complexity and enhances explanatory power. We provide a brief overview of available methods, discuss their strengths and weaknesses and outline methodological challenges. Particular attention is paid to network based pathway enrichment analysis methods due to their superior performance. The methods are illustrated on a number of data sets from diverse Omics technologies.