Institute of Statistical Science Academia Sinica

Education

Ph.D., Statistics, Stanford University, USA ( - 1997)
M.S., Physics, National Taiwan University, Taiwan ( - 1991)
B.S., Physics, National Taiwan University, Taiwan ( - 1989)

Working Experience

Research Fellow, Institute of Statistical Science, Academia Sinica, Taiwan (2013 - Present)
Deputy Director, Institute of Statistical Science, Academia Sinica, Taiwan (2017 - 2021)
Associate Research Fellow, Institute of Statistical Science, Academia Sinica (2003 - 2013)
Senior Statistician, The Stanford Functional Genomics Facility, Stanford University, USA (2002 - 2003)
Statistician, The Stanford Functional Genomics Facility, Stanford University, USA (2001 - 2002)
Postdoctoral Fellow, The Department of Health Research and Policy, Stanford University, USA (1997 - 2000)

Research Interests

Clustering Analysis
Dimension Reduction
Scan Statistics
Statistical Machine learning
cryo-EM Image Analysis
Block Chain

Publications - Journal Papers

Shih-Chi Luo, Min-Chi Yeh, Yu-Hsiang Lien, Hsin-Yi Yeh, Huei-Lun Siao, I-Ping Tu, Peter Chi, Meng-Chiao Ho*,2023-08,A two-stranded RAD51–ADP filament structure unveils the mechanism of filament dynamics in homologous recombination,A two-stranded RAD51–ADP filament structure unveils the mechanism of filament dynamics in homologous recombination,14, 4993
Tze Leung Lai, Shao-Hsuan Wang, Szu-Chi Chung, Wei-hau Chang and (I-Ping Tu)*,2023,Uncertainty Quantiﬁcation in Dynamic Image Reconstruction with Applications to Cryo-EM,Uncertainty Quantiﬁcation in Dynamic Image Reconstruction with Applications to Cryo-EM,33, 1771-1788
Wei-Hau Chang*, Shih-Hsin Huang, Hsin-Hung Lin, Szu-Chi Chung, (I-Ping Tu),2021-12,Cryo-EM Analyses Permit Visualization of Structural Polymorphism of Biological Macromolecules,Frontiers in Bioinformatic,1, 788308
Wei-hau Chang*, I-Kuen Tsai, Shih-Hsin Huang, Hsin-Hung Lin, Szu-Chi Chung, (I-Ping Tu), Steve S.-F. Yu* and Sunney I. Chan*,2021-06,Copper centers in the cryo-EM structure of particulate methane monooxygenase reveal the catalytic machinery of methane oxidation,Copper centers in the cryo-EM structure of particulate methane monooxygenase reveal the catalytic machinery of methane oxidation,143(26), 9922-9932
Shao-Hsuan Wang, Yi-Ching Yao, Wei-Hau Chang and (I-Ping Tu)*,2021,Quantification of model bias underlying the phenomenon of Einstein from Noise,Statistica Sinica ,31, 2355-2379,(IF 0.968)
Chen Ren, (Tu I-Ping), Chuang Kai-Er, Lin Qin-Xue, Liao Shih-Wei, Liao Wanjiun,2020,Endex: Degree of Mining Power Decentralization for Proof-of-Work Based Blockchain Systems,IEEE Network,34(6) 266-271,[SCI],(IF 8.808)
Chung Szu-Chi, Lin Hsin-Hung, Niu Po-Yao, Huang Shih-Hsin, (Tu I-Ping), Chang Wei-Hau,2020,Pre-pro is a fast pre-processor for single-particle cryo-EM by enhancing 2D classification,Communications Biology,3(1), 508-520,[Scopus],[SCI],(IF 4.165)
Szu-Chi Chung, Shao-Hsuan Wang, Po-Yao Niu, Su-Yun Huang, Wei-Hau Chang, (I-Ping Tu),2020,Two-stage dimension reduction for noisy high-dimensional images and application to Cryogenic Electron Microscopy,Annals of Mathematical Sciences and Applications,5(2), 283-316,[Others]
(Tu I-Ping), Huang Su-Yun, Hsieh Dai-Ni,2019-09,The generalized degrees of freedom of multilinear principal component analysis,Journal of Multivariate Analysis,173, 26-37,[SCI],(IF 1.136)
Wu Jheng-Syong, Chen Tzu-Yun, Lin Sam Song-Yao, Lin Shu-Yu, Hung Cheng-Yu, (Tu I-Ping), Chen Hung-Ta, Chang Wei-Hau,2019-04,Deriving a sub-nanomolar affinity peptide from TAP to enable smFRET analysis of RNA polymerase II complexes,Methods,159–160, 59-69,[SCI],(IF 3.812)
Ting-Li Chen, Dai-Ni Hsieh, Hung Hung, I-Ping Tu*, Pei-Shien Wu, Yi-MingWu, Wei-Hau Chang, Su-Yun Huang,2014-04,$gamma$-SUP: a clustering algorithm for cryo-electron microscopy images of asymmetric particles,Annals of Applied Statistics,8(1), 259-285,[SCI],(IF 1.675)
I-Ping Tu*,2013-09,The Maximum of a Ratchet Scanning Process over a Poisson Random Field,STATISTICA SINICA,23, 1541-1551,[SCI],(IF 0.968)
(I-Ping Tu*), Shao-Hsuan Wang and Yuan-Fu Huang ,2013-07,Estimating the Occurrence Rate of DNA Palindromes,Annals of Applied Statistics,7(2): 1095-1110,[SCI],(IF 1.675)
Hung Hung, Pei-Hsien Wu, (I-Ping Tu*) and Su-Yun Huang ,2012-09,On multilinear principal component analysis of order-two tensors,BIOMETRIKA,99(3): 569-583.,[SCI],(IF 1.632)
1. Hao-Chih Lee, Bo-Lin Lin, Wei-Hau Chang and I-Ping Tu*,2012-02,Towards Automated De-Noising of Single Molecular FRET Data: ADN for smFRET,Journal of Biomedical Optics, 17(1),[SCI],(IF 2.785)
Hock Peng Chan, (I-Ping Tu),2011,Log-linear, Logistic Model Fitting and Local Score Statistics for Cluster Detection with Covariate Adjustments,Statistics in Medicine,30, 91-100,[SCI],(IF 1.783)
Yin-Ping Chen, Hsin-Cheng Huang, I-Ping Tu*,2010-12,A New Approach for Selecting the Number of Factors,Computational Statistics & Data Analysis,54, 2990-2998,[SCI],(IF 1.186)
Wei-Hau Chang*, Michael T.-K. Chiu, Chin-Yu Chen, Chi-Fu Yen, Yen-Cheng Lin, Yi-Ping Weng, Ji-Chau Chang, Yi-Min Wu, Holland Cheng, Jianhua Fu "與" I-Ping Tu,2010-08,Zernike phase plate cryo-electron microscopy facilitates single particle analysis of unstained asymmetric protein complexes,Structure,18(8), 903-912,[SCI],(IF 4.862)
I-Ping Tu*, Hung Chen and Xin Chen,2009-10,An Eigenvector Variability Plot ,Statistica Sinica,19, 1741-1754,[SCI],(IF 0.968)
Tu, I-Ping ,2009-01,Asymptotic overshoot for arithmetic IID random variables,Statistica Sinica,19(1), 315-324,[SCI],(IF 0.968)
5. Leung SY, Ho C, Tu IP, Li R, So S, Chu KM, Yuen ST, Chen X.*,2006-06,Comprehensive analysis of 19q12 amplicon in human gastric cancers.,MODERN PATHOLOGY,19(6):854-63,[SCI],(IF 5.988)
I.-P. Tu, M. Schaner, M. Diehn, B.I. Sikic, P.O. Brown, D. Botstein and M. Fero,2004,A method for detecting and correcting gene misidentification on expression microarrays.,BMC Genomics,5(64),[SCI],(IF 3.594)

Publications - Conference Papers

Szu-Chi Chung, Cheng-Yu Hung, Huei-Lun Siao, Hung-Yi Wu, Wei-Hau Chang, (I-Ping Tu)*,2021-08,Cryo-RALib–a modular library for accelerating alignment in cryo-EM,IEEE International Conference on Image Processing (ICIP),225-299
Szu-Chi Chung, Shao-Hsuan Wang, Cheng-Yu Hung, Wei-Hau Chang, (I-Ping Tu),2021-07,rAMI–rapid alignment with moment of inertia for cryo-EM image processing,rAMI–rapid alignment with moment of inertia for cryo-EM image processing,27, 3216-3218
Szu-Chi Chung*, Hung-Yi Wu, Wei-Hau Chang, and (I-Ping Tu),2021,Grouping 3D structure conformations using network analysis on 2D cryo-EM projection images,Focus on Microscopy 2021
Lin Yu-Jing, Wu Po-Wei, Hsu Cheng-Han, (Tu I-Ping), Liao Shih-wei,2019-05,An Evaluation of Bitcoin Address Classification based on Transaction History Summarization,2019 IEEE International Conference on Blockchain and Cryptocurrency (ICBC),9
Chou Chi-Ning, Lin Yu-Jing, Chen Ren, Chang Hsiu-Yao, (Tu I-Ping), Liao Shih-Wei,2018/07,Personalized Difficulty Adjustment for Countering the Double-Spending Attack in Proof-of-Work Consensus Protocols,2018 IEEE International Conference on Internet of Things (iThings) and IEEE Green Computing and Communications (GreenCom) and IEEE Cyber, Physical and Social Computing (CPSCom) and IEEE Smart Data (SmartData),1456-1462
Tu, I-Ping,2007-06,P-Values approximation of scan statistics and its application to genomic data,Symposium on Recent Development of Statistics in Biological Sciences

Publications - Chapter Of The Books

Hock Peng Chan*, I-Ping Tu, Nancy Zhang,2009,Boundary crossing probability computations in the analysis of scan statistics,Scan Statistics--Methods and Applications,87-108

Publications - Technical Reports

Tu,I-Ping 　,2007-08-07,The Maximum of A Ratchet Scan Statistic Over A Poisson Random Field

Faculty